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Signify sildenafil plasma concentrations calculated once the administration of just one oral dose of 100 mg to healthy male volunteers is depicted beneath:
Nevertheless, there aren't any controlled clinical info on the security or efficacy of VIAGRA in clients with sickle mobile or associated anemias.
Viagra er en potenspille som inneholder den aktive ingrediensen sildenafilsitrat i 25mg, 50mg eller 100mg. Den aktive ingrediensen sildenafil er en såkalt PDE5-hemmer som blokkerer PDE5 slik at enzymet cGMP igjen får tid til å fungere.
It is eradicated predominantly by hepatic metabolism (largely CYP3A4) and is particularly transformed to an Lively metabolite with properties much like the dad or mum, sildenafil. Both equally sildenafil as well as metabolite have terminal 50 percent lives of about four several hours.
It's impossible to find out regardless of whether these functions are associated directly to the use of PDE5 inhibitors, to the affected individual's underlying vascular danger aspects or anatomical defects, to a combination of these elements, or to other things [see WARNINGS AND PRECAUTIONS and Client Information and facts].
Physicians need to suggest sufferers from the likely for VIAGRA to augment the blood pressure lowering influence of alpha-blockers and anti-hypertensive remedies. Concomitant administration of VIAGRA and an alpha-blocker may perhaps result in symptomatic hypotension in some sufferers.
If you're feeling faint or dizzy, lie down. Explain to your healthcare provider without delay When you've got any of the next signs or symptoms of reduced hypertension.
[seventy two][73] The Viagra title has grown to be so popular that a lot of fake aphrodisiacs now phone them selves "herbal viagra" or are introduced as blue tablets imitating website The form and colour of copyright's item. Viagra can be informally referred to as "vitamin V", "the blue pill", or "blue diamond", in addition to many other nicknames.
The following gatherings occurred in < two% of clients in controlled medical trials; a causal connection to VIAGRA is unsure. Described activities involve People which has a plausible relation to drug use; omitted are small functions and experiences as well imprecise being meaningful:
sudden eyesight loss in a single or each eyes. Sudden vision decline in a single or equally eyes could be a indicator of a significant eye problem named non-arteritic anterior ischemic optic neuropathy (NAION). Prevent having VIAGRA and contact your healthcare provider without delay In case you have sudden eyesight decline in one or both eyes.
Snakk med lege fileør du tar legemidlet dersom du har høyt blodtrykk som ikke er godt behandlet eller uregelmessige hjerteslag/hjertebank. Les pakningen og pakningsvedlegget nøye før bruk.
Use with warning in people with the following fundamental circumstances which can be significantly sensitive towards the steps of vasodilators such as VIAGRA – those with still left ventricular outflow obstruction (e.
Sildenafil really should not be utilized if sexual action is inadvisable on account of underlying cardiovascular chance factors.[31]